REMEDIA challenge

improve health and reduce the overall burden of disease by addressing the impact of environment on health.


REMEDIA stands as a European Human Exposome research project. Its unique methodology relies on using atmospheric simulation chambers, integrating multiple datasets and applying advanced machine learning approaches.

The overall objective of the REMEDIA project is to determine how and to what extent the exposome affects the severity and morbidity of Chronic Obstructive Pulmonary Disease (COPD) and Cystic Fibrosis (CF) throughout the disease, thus providing key elements to design more tailored prevention and care programs.


What is an exposome?

Despite the general acknowledgement by the scientific community that ‘Genetics load the gun but environment pulls the trigger’ there is persistent uncertainty as to the global burden of disease attributable to environmental factors.

Throughout our lives, we are exposed to a variety of factors, both internal and external, which are a function of our lifestyle, behavior and environment. All these exposures form a concept called “the exposome”.

The concept of exposome reflects the cumulative measure of environmental influences and associated biological responses from the perinatal period onwards. Its importance to health and disease is undeniable and the exposome of each individual could completely interact with the way chronic diseases develop and evolve.


Why a focus on lung diseases?

An estimated 12.6 million deaths each year are attributable to unsanitary environments. Of these deaths, 7 million are caused by air pollution leading to chronic respiratory diseases, which are considered one of the leading causes of environment-related deaths.

Among these chronic respiratory diseases, COPD and CF are two highly debilitating diseases that are of particular interest to consider in parallel in a human exposome study. Indeed, the two diseases share common characteristics, yet their roots seem to be opposite: COPD appears to be intricately related to the exposome and CF not.


An extended under-standing

The REMEDIA project focuses on the impact of the exposome on the course of two lung diseases: Chronic Obstructive Pulmonary Disease (COPD) and Cystic Fibrosis (CF).

The overall research which will cover the entire life-stages data, will help to detect the most influent exposome components on the development and outcomes of lung diseases through life. To achieve this goal, the REMEDIA project will provide a toolbox allowing the development and tailoring of prevention recommendations and treatment guidelines.


Toolbox Database

An integration of multiple datasets 
gathering phenotype and exposome information.


A versatile atmospheric simulation chamber  
targeting specific complex exposomes.


A sensor device  
combining environmental and biomarker toolkits, flexible in terms of targeted pollutants and biomarkers.


A machine learning supervised analysis  
using artificial intelligence techniques to predict health outcomes according to risk profiles.


A Pan-European multi-criteria risk assessment tool  
mapping the overall exposome risk-related pulmonary diseases in Europe.


Cost-effectiveness models
assessing the costs, performance and cost-effectiveness of a selection of prevention strategies targeting exposome risk factors.


Econometric models
testing the interactions between economic, environmental and epidemiological variables.


A causal inference model
allowing the identification of relevant risk factors.


New guidelines and recommendations
based on REMEDIA findings to better predict disease risks.