Methodology
The overall objective is to extend the understanding of the contribution of the exposome, taken as a complex set of different components, to COPD and CF diseases.
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Research questions
Specific questions will be addressed:
- Is there specific exposome(s) associated with particular COPD in terms of severity, morbidity, exacerbations and comorbidities?
- Is there specific exposome(s) associated with particular CF in terms of severity, morbidity, exacerbations and comorbidities?
- Is there specific exposome(s) linked to lung function trajectories and maximal achieved lung function at early adulthood?
- How do similar exposomes impact COPD and CF?
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Innovative approach
A clear multidisciplinary dimension with the collaboration of expert leaders in their respective fields.
The use of up-to-date technologies including atmospheric simulation chamber, lipidomic and epigenetic analyses.
The study of data covering different stages throughout life: from prenatal (during pregnancy) to adulthood.
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Gathered expertise of epidemiologists and public health specialists, adult and pediatrician lung specialists, physico-chemist of the atmosphere, biologists, engineer for sensor development, economists, ethics and legal specialists, and management and technology transfer.
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Global methodological approach
REMEDIA methodological approach is based on 3 steps: data integration, experimental work and computational analyses.
Data integration
6 well-designed existing cohorts and population registries are participating in the REMEDIA project:
- French Registry of CF patients
- Danish Cancer Health (DCH) cohort
- Danish hospital registry
- Norwegian Women and Cancer Cohort (NOWAC) cohort
- ALSPAC cohort (UK)
- French PELAGIE cohort
From these 6 cohorts and registries, data collection and enrichment with environmental information will be carried out and targeted OMICs analyses will be perfomed. An exposome modeling will be conducted using an exposome-wide association study (EWAS) approach.
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CLINICAL
DATA
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Exposome
Modelisation
Experimental work
REMEDIA will develop a sensor combining environmental and clinical measurements.
REMEDIA will also work on the simulation of complex exposomes using two atmospheric simulation chambers available in the consortium.
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Sensor
development
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Simulation in
Preclinical models
Computational Analysis
From the data generated and collected during the two previous steps, a risk assessment and an economic evaluation will be conducted providing useful tools to implement effective prevention strategies.
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Risk
Assessments
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Economic
Modelling
Dissemination
REMEDIA is committed to communicating and disseminating its results through conferences and publications involving different stakeholders (scientific community, policy makers, civil society)
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Network
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Conferences