Publication on European Journal of Public Health
Associations between prenatal exposure to outdoor PM2.5 and NO2 and childhood respiratory symptoms
Authors: A R Patlan Hernandez, E Audureau, C Monfort, R Epaud, S Lanone, M Nieuwenhuijsen, M de Castro, C Warembourg, C Chevrier, B Jacquemin
Background: Prenatal and early-life air pollution exposures have shown to play an important role in childhood respiratory and allergic diseases development. Our aim was to assess the effect of prenatal exposure to air pollution on several respiratory outcomes up to 12 years old.
Methods: We included 2054 children from the PELAGIE mother-child cohort in Brittany, France, followed-up at 2-, 6- or 12-years. Parents reported children’s respiratory health history, family lifestyle and children immediate environment. PM2.5 and NO2 mean concentrations throughout the pregnancy were modelled at residential address using land use regression models. Ever asthma, rhinitis, allergic rhinitis and eczema at 12-years follow-up, considered as outcomes of interest, were defined using validated questionnaires. A multimorbidity phenotype was also constructed. We performed adjusted logistic regressions per increase of one interquartile range (IQR).
