Institut National de la Santé et de la Recherche Médicale (Inserm)
Founded in 1964, INSERM is a public scientific and technological institute, which operates under the joint authority of the French Ministries of Health and Research. The institute is dedicated to biomedical research and human health, and is involved in the entire range of activities from the laboratory to the patient’s bedside. It also partners with the most prestigious research institutions in the world that are committed to scientific challenges and progress in these fields. INSERM will be participating with 3 teams in REMEDIA.
Gene-Environment interactions in COPD, CF and other Chronic lung diseases team
Scientific project manager
Audrey Der Vartanian
The GEIC2O team is a research team of the Mondor Institute of Biomedical Research (IMRB).
The general scientific objective of GEIC2O team is to understand the interplay between genetic and environmental factors in the development of lung diseases throughout the life (namely from children to adults).
We particularly focus on lung diseases of non-genetic (Chronic Obstructive Pulmonary Disease or COPD) and genetic (Cystic Fibrosis and surfactant disorders) origins.
The large pluridisciplinarity of GEIC2O team staff comprising MD (lung specialists – adult and pediatricians, occupational medicine, geneticists, ear/nose/throat specialists, and lung pathologist) as well as PhD (in cellular and molecular biology, biochemistry, genetic, bioinformatics and respiratory physiology) allows us to develop a comprehensive scientific approach ranging from in vitro experimental work to preclinical models and patient cohorts.
Four main research axes:
- Molecular bases of cigarette smoke-induced COPD
- Genetic and cellular bases of CF and surfactant disorders
- Resolution of inflammation in lung diseases – New theme
- Environmental aggressions and course of lung diseases
Clinical Epidemiology and Ageing team
WP2 and WP5 co-leader
The CEpiA team is a research team of the Mondor Institute of Biomedical Research (IMRB) focusing on developing geriatric clinical epidemiology and studies aimed at improving understanding of the ageing processes leading to frailty and multimorbidity, both at the hospital level and in primary care setting.
CEpiA is a multidisciplinary team that gathers the complementary capabilities of epidemiologists and biostatisticians, geriatricians and general practitioners involved in both academic primary care research and clinical practice in the field.
CEpiA has gained an expertise in handling large scale long-term follow-up cohorts (ELCAPA cohort, N=3000 older cancer patients enrolled; SUCCEED study >700 patients aged over 50 years enrolled), in building of predictive models based on clinic biological markers and in analysing and mining large databases such as the French claims database linked to hospital discharge database in geriatric setting, or the OMG (Observatoire de Médecine Générale).
Research Institute for Environmental and Occupational Health team
Headed by Dr Bernard Jégou, this team is part of the Research Institute for Environmental and Occupational Health (IRSET – INSERM Unit 1085) is composed of ten teams focused on well identified research areas, and two R&D platforms.
Its mission is to improve human health by studying biological processes and environmental factors that influence them, and to enable public authorities to make informed decisions.
To do so, IRSET is a multidisciplinary, interdisciplinary and transdisciplinary research center fostering tight links between different facets of research, training, expertise, technology, and clinical studies, with the ultimate aim to better understand the effects of environmental factors – physical, chemical (from industrial, agricultural, urban and pharmaceutical origins), biological, sociocultural – and their possible interactions on human.