Pelagie

Pélagie (Perturbateurs Endocriniens: Étude Longitudinale sur les Anomalies de la Grossesse, l’Infertilité et l’Enfance (Endocrine Disruptors: Longitudinal Study of Pregnancy, Infertility and Childhood Abnormalities), is a mother-child cohort that recruited pregnant women in their first trimester of pregnancy (<19 weeks of gestation) who resided in the Brittany region, France, from 2002 to 2005. 3,421 participants from more than 40 different health centers were included during prenatal care visits to gynecologists, obstetricians, midwives, or ultra-sonographers. This prospective cohort follows-up individuals from birth all the way up to early adulthood. Children have participated in 3 follow-ups after birth; one at 2 years old (2004 to 2008), one at 6 years old (2008 to 2012), and finally at 12 years old (2015 to 2022). A fourth follow-up at 18-20 years old has started during the last quarter of 2022 and is ongoing.

The Pélagie database integrates various types of data, including clinical examination, self-reported, and biological data. Pélagie aims to assess the effects of environmental and occupational exposures on children’s health. Specifically, the study focuses on prenatal exposure to solvents, pesticides, persistent organic pollutants, and chlorination byproducts and their impact on pregnancy, perinatal outcomes, and child development. Pélagie also aims to identify the sources and determinants of exposure, as measured by biomarkers, and to investigate the individual impacts of prenatal and childhood exposures. Moreover, with this cohort, researchers aim to better understand the complex interplay between environmental and lifestyle factors, socio-demographic characteristics, genetic susceptibility, and their potential influence on child health.

Summary data table

To come…