A VERSATILE ATMOSPHERIC SIMULATION CHAMBER
A versatile atmospheric simulation chamber targeting specific complex exposomes
The health impacts of the external exposome identified in the other parts of REMEDIA are identified and quantified in naïve, COPD or CF preclinical models.
Our strategy is to couple an atmospheric simulation chamber, where the complexity of real atmosphere is reproduced, to cabinets where preclinical models are exposed.
Principle of the PolluRisk Platform (here in a “Beijing-type” atmospheric simulation)
Two complementary simulation chambers are used in the project: a mobile Teflon chamber (ASC, @FORTH) that can interact directly with the solar radiation, and a stainless-steel chamber of higher volume (CESAM, @LISA), which allows longer-term exposures that are essential for the simulation of chronic lung diseases. Other components of the exposome (stress, physical activity, noise, etc.) will also be implemented, depending on findings obtained in the data integration part of the project. Preclinical models will be exposed to the different exposomes at various periods of their lives and health endpoints such as lung function (trajectories) will be studied.
View of the Pollurisk Platform
Leader and co-leader:
Contacts:
Patrice Coll
Target users: Scientists